Longevity & AgingMitochondria Are the Master Key to Healthy Aging and Disease Prevention
This editorial synthesizes findings from a special issue of Aging and Disease, establishing mitochondrial dysfunction as a unifying mechanism across aging and major age-related conditions including Alzheimer's, Parkinson's, cardiovascular disease, Down syndrome, and sarcopenia. Key molecular culprits include impaired oxidative phosphorylation, elevated reactive oxygen species, damaged mitochondrial DNA, disrupted mitophagy, and failed inter-organelle communication. The editorial highlights emerging therapeutic strategies—from mitochondrial transplantation and exercise-activated signaling pathways to antioxidants and gene therapy—that target mitochondrial restoration. With over 300 recognized mitochondrial disorders, the authors argue that investment in mitochondrial medicine is now essential to extending both lifespan and healthspan.
