20 artigos
New guidance on using clonal hematopoiesis markers and inherited syndrome testing to evaluate cytopenias and bone marrow failure.
Blood stem cell mutations may actually improve immune checkpoint therapy effectiveness against cancer tumors.
Mutações em fatores de splicing resgatam células-tronco sanguíneas do encurtamento dos telômeros, revelando um novo mecanismo que conecta envelhecimento, hematopoiese clonal e risco de leucemia.
New research explores how naturally occurring aldehydes in our bodies might trigger clonal hematopoiesis, a blood disorder linked to aging.
A proteômica em larga escala revela padrões distintos de proteínas plasmáticas associados a mutações em DNMT3A, TET2 e outras mutações de hematopoiese clonal, iluminando vias inflamatórias.
New research reveals how thrombopoietin hormone establishes lifelong blood stem cell hierarchy in newborns.
New research reveals how endogenous formaldehyde causes stem cell damage, leading to clonal blood disorders throughout life.
Scientists review how hematopoietic stem cells become senescent with age and identify promising therapeutic strategies to restore blood system function.
A major review outlines how targeted hematologic therapies are transforming outcomes in MGRS, a rare but serious cause of kidney injury.
Scientists identify key molecular pathways that distinguish different types of anemia, opening doors to precision treatments.
Cientistas geram verdadeiras células-tronco hematopoéticas a partir de iPSCs humanas que repovoam múltiplas linhagens sanguíneas a longo prazo, rivalizado com transplantes de sangue de cordão umbilical.
Researchers identify four LSC subtypes that predict venetoclax resistance and reveal matched subtype-specific therapies for AML patients.
A microbial sugar molecule leaking from an aging gut selectively expands pre-leukemic blood stem cells, revealing a new therapeutic target.
A landmark Nature study shows metformin can suppress the clonal advantage of DNMT3A-mutant blood stem cells, potentially preventing leukemia progression.
New research reveals how age-related blood cell changes may increase pericarditis and myocarditis risk in healthy adults.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity — not just cell diversity — as the core therapeutic target.
New research reveals how aging blood stem cells trigger inflammation and immune dysfunction that accelerates aging throughout the body.
Cientistas revelam como linfomas com duplo impacto MYC/BCL2 escapam da sinalização BCR e identificam novas vulnerabilidades terapêuticas nesse câncer letal.
A landmark multi-omic study maps the full metabolic landscape of human bone marrow stem cells, revealing choline as a key stemness regulator.
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
