Epigenetic Reprogramming Shapes Early Mammalian Development
New review explores how epigenetic changes control the earliest stages of mammalian embryo development and cellular identity.
20 articles
New review explores how epigenetic changes control the earliest stages of mammalian embryo development and cellular identity.
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Chinese researchers decode how chemical cocktails alone can convert adult human cells into pluripotent stem cells, bypassing gene editing.
New research reveals how partial cellular reprogramming consistently modulates key aging processes across species and cell types.
New research reveals how a regulatory protein prevents harmful epigenetic changes during embryo development.
Comprehensive review reveals how epigenetic drift drives aging and outlines promising rejuvenation strategies including CRISPR editing and reprogramming.
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
Researchers erased imprinting marks in mouse sperm using dCas9-TET1, then traced how methylation partially recovered — fingering H3K9me3 as the key mediator.
New research reveals how stem cell reprogramming can reset aging markers and extend lifespan in mouse models.
New research reveals why stem cells from Alzheimer's patients retain disease signatures that affect brain development.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
Biotech startup NewLimit is screening transcription factors to reverse cellular aging via partial reprogramming and mRNA delivery.
A landmark Cell study reveals p53 actively enables chemical reprogramming to pluripotency, overturning assumptions and boosting regenerative medicine safety.
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
New small-molecule approach offers safer alternative to genetic reprogramming for turning back the cellular clock.
A lysosome-to-epigenome pathway in C. elegans extends lifespan across multiple generations via histone H3.3 transport from gut to germline.
Researchers discover that viscoelastic substrates enhance cellular plasticity by altering chromatin structure and improving reprogramming efficiency.