Longevity & Aging
Epigenetic Reprogramming Shapes Early Mammalian Development
New review explores how epigenetic changes control the earliest stages of mammalian embryo development and cellular identity.
Research Paper
Apr 2, 2026 0
Results for "Partial Epigenetic Reprogramming"
20 articles
Regenerative Medicine
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Partial Reprogramming at the Frontier: Mechanisms, Safety, and Therapeutic Translation
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
TutorialAdvanced
Apr 23, 2026 0
Regenerative Medicine
Premium
The Molecular Machinery of Reprogramming: How OSKM Rewrites Cellular Identity
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
TutorialIntermediate
Apr 22, 2026 0
Regenerative Medicine
Small Molecules Reprogram Human Cells Without Genetic Engineering
Chinese researchers decode how chemical cocktails alone can convert adult human cells into pluripotent stem cells, bypassing gene editing.
Research Paper
May 12, 2026 0
Longevity & Aging
Partial Cell Reprogramming Shows Promise for Reversing Aging at the Cellular Level
New research reveals how partial cellular reprogramming consistently modulates key aging processes across species and cell types.
Research Paper
Apr 6, 2026 0
Longevity & Aging
Protein EZHIP Controls Epigenetic Memory Transfer from Parents to Offspring
New research reveals how a regulatory protein prevents harmful epigenetic changes during embryo development.
Research Paper
Apr 7, 2026 0
Longevity & Aging
Epigenetic Aging Can Be Reversed Through DNA Methylation and Chromatin Reprogramming
Comprehensive review reveals how epigenetic drift drives aging and outlines promising rejuvenation strategies including CRISPR editing and reprogramming.
Research Paper
Apr 6, 2026 0
Gut & Microbiome
Gut Microbes Reprogram Host DNA Through Methylation Pathways
Comprehensive review reveals how gut bacteria modify human gene expression through epigenetic mechanisms, opening new therapeutic avenues.
Research Paper
Apr 4, 2026 0
Regenerative Medicine
From Aging Theories to Epigenetic Reprogramming: A Field in Transformation
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
Review
Jun 30, 2026 0
Longevity & Aging
Partial Cellular Reprogramming Reverses Aging Without Cancer Risk
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
Research Paper
Apr 6, 2026 0
Brain Health
Partial Reprogramming of Memory Cells Reverses Cognitive Aging in Mice
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
Research Paper
Jun 22, 2026 0
Regenerative Medicine
H3K9me3 Histone Mark Drives DNA Methylation Recovery After Germline Epigenome Editing
Researchers erased imprinting marks in mouse sperm using dCas9-TET1, then traced how methylation partially recovered — fingering H3K9me3 as the key mediator.
Research Paper
May 14, 2026 0
Longevity & Aging
iPSC Reprogramming Shows Promise for Reversing Cellular Aging and Age-Related Disease
New research reveals how stem cell reprogramming can reset aging markers and extend lifespan in mouse models.
Research Paper
Apr 6, 2026 0
Longevity & Aging
Alzheimer's Cells Keep Disease Memory Even After Cellular Reprogramming
New research reveals why stem cells from Alzheimer's patients retain disease signatures that affect brain development.
Research Paper
Mar 28, 2026 0
Regenerative Medicine
Partial Reprogramming Resets Eye Cell Epigenetic Clocks in Living Humans
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
Press Release
Apr 19, 2026 0
Cancer Research
Nuclear Enzyme Breakthrough Reprograms Cancer Cells to Stop Growing
Scientists discover how to reprogram cancer cells into harmless, non-dividing cells by targeting a nuclear enzyme pathway.
Research Paper
Mar 29, 2026 1
Regenerative Medicine
Scientists Engineer a Tool to Precisely Edit Mitochondrial DNA Methylation Linked to Aging
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
Research Paper
Jun 28, 2026 0
Longevity & Aging
NewLimit Is Using Epigenetic Reprogramming to Turn Back the Clock on Human Cells
Biotech startup NewLimit is screening transcription factors to reverse cellular aging via partial reprogramming and mRNA delivery.
Video
Jun 26, 2026 0
Regenerative Medicine
p53 Tumor Suppressor Proves Essential for Safer Stem Cell Reprogramming
A landmark Cell study reveals p53 actively enables chemical reprogramming to pluripotency, overturning assumptions and boosting regenerative medicine safety.
Research Paper
Apr 19, 2026 0
Longevity & Aging
Partial Reprogramming Reverses Mesenchymal Drift That Drives Aging and Disease
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
Research Paper
Mar 29, 2026 0
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