Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1273 articles
Newly characterized lipid mediators derived from DHA may defend against Alzheimer's, Parkinson's, stroke, and macular degeneration.
The TCA cycle is a central metabolic hub linking energy production, amino acid synthesis, and cholesterol regulation — all critical to aging biology.
Scientists created stem cell models of Wiedemann-Rautenstrauch syndrome, uncovering how POLR3A mutations disrupt nucleoli and trap telomerase RNA.
A comprehensive 2025 review charts the signaling pathways, drug targets, and emerging strategies scientists are using to slow human aging.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
A 24,853-person Norwegian cohort study finds that maintaining cardiorespiratory fitness above the bottom 20% largely offsets alcohol's mortality risk.
Scientists reveal how thymine DNA glycosylase removes the adenine oxidation lesion oxoA, a DNA damage implicated in cancer and aging.
A new lipid-based aging clock built from prefrontal cortex lipidomics detects accelerated aging in autism, schizophrenia, and Down syndrome.
Australian expert panel issues landmark 2025 recommendations on managing semaglutide, tirzepatide, and related drugs around surgical and endoscopic procedures.
A new 86-protein score called HPS predicts healthspan with greater accuracy than existing biological age clocks across 53,000 UK Biobank participants.
Scientists boosted a protein that dampens chronic inflammation, and older mice grew stronger, more energetic, and had healthier bones.
A topical senolytic drug cleared aging 'zombie' cells from old skin, helping aged mice heal wounds 43% more completely by day 24.
