Autoimmune diseases, immune modulation, inflammation, and self-tolerance
202 articles
Discover how a hidden arm of your immune system called the complement system quietly drives the chronic inflammation linked to aging — and what you can do about it.
A Phase 2 trial testing rituximab, infliximab, and tocilizumab for hard-to-treat non-ANCA vasculitis was terminated before completion.
A multi-biomarker study finds pwMS show accelerated thymic involution, senescent T cell expansion, and neuroinflammation linked to aging.
A comparative protein interaction map of SARS-CoV-2 and its bat progenitor uncovers the molecular switch behind immune evasion and species barriers.
A newly identified immune axis involving CD16+ γδ T cells and antibody-dependent killing may reshape how we understand HBV immune control.
A runaway immune response — not the pathogen itself — drives citrus greening disease, echoing autoimmune mechanisms seen in human illness.
A novel biologic targeting IL-33 shows promising advances in COPD treatment, potentially reshaping how chronic lung disease is managed.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
JAMA publishes a timely review of IgA nephropathy, the leading cause of primary glomerulonephritis worldwide, amid a wave of new therapies.
Nephrologists from Canada and Ireland address clinical questions on IgA nephropathy, one of the most common causes of kidney failure worldwide.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
