Autoimmune diseases, immune modulation, inflammation, and self-tolerance
235 articles
A deep mechanistic exploration of neutrophil extracellular trap biology in the context of aging — from PAD4 citrullination dynamics and gasdermin-driven release to clinical immunopathology and next-generation therapeutic targets.
A massive viral gene library exposes hundreds of proteins that suppress immune detection — with major implications for infection, cancer, and aging.
Authors reply to commentary on a landmark NEJM trial combining ianalumab and eltrombopag for immune thrombocytopenia.
Experts argue that finding new autoantibodies in encephalitis is yielding diminishing returns and call for a shift in research priorities.
Go deeper into the molecular machinery of neutrophil extracellular traps — how they form, what activates them with age, and why clearing them becomes increasingly difficult over time.
A systematic review of 90 studies reveals mTOR both drives MS inflammation and is essential for myelin repair — complicating treatment strategies.
Discover how your immune cells set microscopic traps to fight infections — and why those same traps can silently fuel inflammation and speed up aging.
A new Cell Metabolism review reveals how redox imbalance breaks immune tolerance, fueling lupus, rheumatoid arthritis, and MS.
A 205,000-person UK Biobank study finds the EAT-Lancet diet reduces RA risk, with omega-3s and anti-inflammatory metabolites driving one-third of the benefit.
Researchers at Assiut University investigated whether COVID-19 infection triggers serious blood disorders including aplastic anemia and immune cytopenias.
Intermittent fasting reshapes gut microbiota and bile acids to reduce autoimmune inflammation in the lacrimal gland, improving dry eye in mice.
A new review reveals how diet, exercise, and stress reduction can measurably reverse key markers of immune aging and inflammaging.
