Autoimmune diseases, immune modulation, inflammation, and self-tolerance
202 articles
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
Early influenza infections leave a lasting immunological imprint that determines how your immune system responds to entirely different flu strains later in life.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
A new in vitro study shows Thymosin α1 triggers dendritic cells to release IL-15, boosting CD8+ T cell killing and reducing HIV reservoir size.
A clinical case from Japan illustrates how cryoglobulinemia can drive membranoproliferative glomerulonephritis, a serious kidney complication.
A major review maps emerging immunotherapies—from JAK inhibitors to microbiome interventions—that could transform care for celiac and food allergy patients.
New research reveals that mitochondrial energy pathways directly govern dendritic cell immune activation, with major implications for cancer and autoimmune therapies.
Mice lacking the PERP apoptosis gene develop faulty thymic immune screening, accumulating self-reactive T-cells that trigger arthritis as they age.
Pyruvate, a core metabolic molecule, suppresses interferon signaling by directly modifying STAT1 — linking metabolism to immune control.
A bibliometric analysis of 7,037 studies reveals gut microbiota, fibroblast-like synoviocytes, and biologic therapy as the emerging frontiers in RA immunology.
New biomarker in joint tissue correlates with inflammation severity and may explain why some patients don't respond to corticosteroids.
