Gut microbiome, probiotics, gut-brain axis, and digestive health
322 articles
New organoid research shows aged gut microbiota metabolites can directly induce aging changes in intestinal epithelium, pointing to microbiome as a key target.
New research reveals gut microbes actively regulate interoception — the brain's ability to sense internal body states — with major implications for health.
A heat-treated postbiotic reshapes gut microbiota and metabolites, reducing IBS symptoms and improving quality of life in 8 weeks.
A 23-study meta-analysis finds alpha-diversity cannot distinguish Alzheimer's or MCI from normal aging, but community structure shifts show more promise.
Bacteroides fragilis produces pantothenic acid in the gut, and restoring this supply reverses metabolic syndrome in animal models.
A mouse study shows CD38 inhibition protects colon architecture during 5-FU chemotherapy by preventing NAD+ depletion.
A new study maps how skin bacteria and fungi shift across the human lifespan, revealing sex differences and a four-marker microbial model that classifies age groups with AUC 0.97.
Spatial proteomics reveals how aging reshapes the gut's immune landscape — and points to metformin and senolytics as potential fixes.
Two large randomized trial cohorts show H. pylori infection raises colorectal cancer risk, and eradication therapy offers lasting protection.
Random forest models using just 5 bacterial markers accurately distinguish gum, plaque, and saliva microbiomes in healthy adults.
New metapangenomic analysis reveals that oral Porphyromonas species occupy distinct mouth niches, with P. gingivalis found in only 42% of periodontitis cases.
A 28-cohort metagenomic meta-analysis identifies 16 gut microbial biomarkers that detect frailty across cultures with ~76% accuracy.
