Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,773 articles
A new review argues that systemic blood recalibration and partial cellular reprogramming target different axes of aging and should be combined.
A systematic review of 27 human trials finds calorie restriction best modulates senescence markers, but direct evidence remains elusive.
A comprehensive review of hyperphosphatemia covers phosphate physiology, hormonal regulation, and clinical consequences for aging and kidney health.
New review reveals how declining Klotho levels drive insulin resistance and type 2 diabetes, positioning this anti-aging protein as a potential biomarker.
A meta-analysis of 38 studies reveals older heart failure patients have dramatically lower peak oxygen uptake than controls, declining further with each decade.
Cardiorespiratory fitness independently predicts morbidity and mortality. Danish review explains why VO₂max may be your most important health metric.
A landmark review maps the dose-response curve between cardiorespiratory fitness and mortality, revealing J-shaped risks at exercise extremes.
Celastrol outperforms leading senolytics by targeting the Hsc70-Bim protein complex, clearing zombie cells and reducing organ fibrosis in mice and flies.
An 8-hour feeding window extended median lifespan in male mice by 12%, though caloric restriction may explain part of the benefit.
Early data show sustained telomere lengthening in blood cells, while a new licensing deal advances a dystrophin therapy for Duchenne muscular dystrophy.
The Forever Healthy Foundation adds a transparent, AI-assisted peptide evidence library to help cut through hype and find real clinical signal.
A liver-specific protein triggers aging not through cell death, but by spreading senescence via mitochondrial dysfunction and inflammatory signals.
