Longevity & AgingLargest Multiomics Study Reveals How Ancestry and Geography Shape Human Biology
Researchers at Stanford and collaborating institutions performed one of the most comprehensive multiomics analyses to date, profiling 322 healthy individuals of European, East Asian, and South Asian ancestry across multiple continents. Using eight omics layers — genomics, transcriptomics, proteomics, metabolomics, lipidomics, metallomics, glycomics, and microbiomics — the team identified molecular signatures tied to ancestry, geography, and age. Key findings include ethnicity-linked differences in drug metabolism, autoimmune disease risk, and lipid regulation, as well as geography-dependent shifts in biological aging. East Asians living in ancestral regions showed lower biological age, while Europeans in North America showed lower biological age than those in Europe. Diet-microbiome interactions also varied meaningfully by ethnicity, with many patterns relevant to health outcomes.
