20 artigos
Comprehensive review reveals how immunosenescence creates tumor-promoting environments and reduces treatment effectiveness in elderly cancer patients.
Vá além do básico do inflammaging para entender como o envelhecimento remodela as populações de células imunes, desencadeia o SASP e mantém o organismo em um estado de inflamação crônica de baixo grau no nível molecular.
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
A landmark 2025 review maps the molecular and cellular mechanisms driving immune aging, linking inflammaging to cancer, neurodegeneration, and infection.
Immunosenescence reshapes immune function in ways that fuel autoimmune disease — and new therapies targeting aging immune cells may reverse the damage.
Uma análise mecanicista aprofundada das intervenções de ponta contra o inflamaging — da farmacologia senolítica e do direcionamento preciso de citocinas às estratégias de reprogramação parcial que visam restaurar a homeostase imunológica juvenil.
Researchers show that enhancing thymic epithelial cell activity in aged mice rebuilds naïve T-cell populations and dramatically improves survival after infection.
New research reveals why some aging cells evade immune detection while others don't, opening doors for targeted therapies.
A landmark review reveals why aging immune systems lose the ability to clear senescent cells — and how new therapies could restore this critical defense.
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
Researchers found a way to restore aging stem cells' healing power, potentially improving treatments for immune diseases.
Harvard researchers identify a rare mesenchymal cell type that regenerates the thymus and boosts T cell immunity in aged animals.
A landmark review reveals the molecular pathways driving thymic self-repair after injury, with major implications for aging immunity.
Nova pesquisa revela como o envelhecimento transforma células imunológicas protetoras em impulsionadoras de inflamação, senescência e dano tecidual.
New precision approach safely rejuvenates senescent cells using targeted gene therapy, extending lifespan in mice.
Restoring NAD+ levels in elderly patients' T cells reverses age-related dysfunction, offering a new 'Metabolic-Immunotherapy' approach for cancer treatment.
Phase 2 trial combining senescent cell-clearing drugs with anti-PD-1 therapy achieved 33% response rate in head and neck cancer patients.
New single-cell sequencing methods uncover previously unknown changes in immune cells during aging, opening doors to personalized treatments.
Eliminar células zumbis e depois restaurar a atividade das células-tronco produziu ganhos na expectativa de vida muito maiores do que cada abordagem isoladamente.
