20 articles
Comprehensive review reveals how immunosenescence creates tumor-promoting environments and reduces treatment effectiveness in elderly cancer patients.
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
A landmark 2025 review maps the molecular and cellular mechanisms driving immune aging, linking inflammaging to cancer, neurodegeneration, and infection.
Immunosenescence reshapes immune function in ways that fuel autoimmune disease — and new therapies targeting aging immune cells may reverse the damage.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
Researchers show that enhancing thymic epithelial cell activity in aged mice rebuilds naïve T-cell populations and dramatically improves survival after infection.
New research reveals why some aging cells evade immune detection while others don't, opening doors for targeted therapies.
A landmark review reveals why aging immune systems lose the ability to clear senescent cells — and how new therapies could restore this critical defense.
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
Researchers found a way to restore aging stem cells' healing power, potentially improving treatments for immune diseases.
Harvard researchers identify a rare mesenchymal cell type that regenerates the thymus and boosts T cell immunity in aged animals.
A landmark review reveals the molecular pathways driving thymic self-repair after injury, with major implications for aging immunity.
New precision approach safely rejuvenates senescent cells using targeted gene therapy, extending lifespan in mice.
Restoring NAD+ levels in elderly patients' T cells reverses age-related dysfunction, offering a new 'Metabolic-Immunotherapy' approach for cancer treatment.
Phase 2 trial combining senescent cell-clearing drugs with anti-PD-1 therapy achieved 33% response rate in head and neck cancer patients.
New single-cell sequencing methods uncover previously unknown changes in immune cells during aging, opening doors to personalized treatments.
Clearing zombie cells then restoring stem cell activity produced far greater lifespan gains than either approach alone.
New research reveals how stem cell reprogramming can reset aging markers and extend lifespan in mouse models.
