20 artigos
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Comprehensive review reveals how telomerase biogenesis regulates telomere maintenance, offering new therapeutic targets for aging disorders.
Deep dive into telomere biology, exploring how telomerase regulation and shelterin complex dynamics control cellular aging and senescence pathways.
A RNA de telomerase modificada (eTERC) alonga os telômeros em iPSCs de pacientes e células-tronco do sangue, oferecendo uma potencial terapia para distúrbios da biologia dos telômeros.
Scientists discover a circular RNA that reactivates telomerase enzyme, extending telomeres and reversing aging markers in cells and tissues.
New research reveals hTERT can prevent cellular aging through telomere compaction rather than lengthening, challenging current understanding.
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
A sweeping review maps how telomerase inhibitors evolved from lab concept to approved drug, spotlighting imetelstat's landmark approval in blood cancers.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
Breakthrough imaging reveals how telomerase protects chromosome ends, offering new insights into cellular aging mechanisms.
New structural insights show how telomerase enzymes pair up through H/ACA RNA complexes, advancing our understanding of cellular aging mechanisms.
END-seq revela que os telômeros de cânceres ALT-positivos compartilham os terminais canônicos 5′ ATC com células normais, mas abrigam regiões de DNA de fita simples excepcionalmente abundantes.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
Cientistas desenvolveram o NU-PRO-1, um PROTAC covalente inédito que degrada a transcriptase reversa da telomerase, com potencial para superar a resistência à terapia contra o câncer.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
Um novo estudo em levedura revela que os telômeros podem autorregular seu comprimento de forma independente por meio do recrutamento de Sir4-telomerase, reformulando nossa compreensão do envelhecimento.
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
A 2025 study shows epitalon lengthens telomeres in normal cells via telomerase and in cancer cells via ALT, offering new anti-aging insights.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
