20 articles
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Comprehensive review reveals how telomerase biogenesis regulates telomere maintenance, offering new therapeutic targets for aging disorders.
Deep dive into telomere biology, exploring how telomerase regulation and shelterin complex dynamics control cellular aging and senescence pathways.
Engineered telomerase RNA (eTERC) lengthens telomeres in patient iPSCs and blood stem cells, offering a potential therapy for telomere biology disorders.
Scientists discover a circular RNA that reactivates telomerase enzyme, extending telomeres and reversing aging markers in cells and tissues.
New research reveals hTERT can prevent cellular aging through telomere compaction rather than lengthening, challenging current understanding.
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
A sweeping review maps how telomerase inhibitors evolved from lab concept to approved drug, spotlighting imetelstat's landmark approval in blood cancers.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
Breakthrough imaging reveals how telomerase protects chromosome ends, offering new insights into cellular aging mechanisms.
New structural insights show how telomerase enzymes pair up through H/ACA RNA complexes, advancing our understanding of cellular aging mechanisms.
END-seq reveals ALT-positive cancer telomeres share canonical 5′ ATC termini with normal cells, but harbor uniquely abundant single-stranded DNA regions.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
Scientists engineered NU-PRO-1, a first-of-its-kind covalent PROTAC that degrades telomerase reverse transcriptase, potentially overcoming cancer therapy resistance.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
A new yeast study reveals telomeres can self-regulate their length independently via Sir4-telomerase recruitment, reshaping our understanding of aging.
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
A 2025 study shows epitalon lengthens telomeres in normal cells via telomerase and in cancer cells via ALT, offering new anti-aging insights.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
