Longevity & AgingFisetin Reverses Chemo-Induced Vascular Aging by Clearing Senescent Cells
Doxorubicin chemotherapy accelerates vascular aging by flooding arteries with senescent cells and inflammatory SASP factors, reducing nitric oxide and stiffening arteries. Researchers at the University of Colorado tested fisetin, a natural flavonoid senolytic found in strawberries and apples, in both human endothelial cells and young adult mice after doxorubicin exposure. Oral intermittent fisetin supplementation (100 mg/kg/day, 1 week on / 2 weeks off / 1 week on) significantly reduced vascular senescent cell burden, lowered SASP expression, restored nitric oxide bioavailability, cut mitochondrial oxidative stress, and reversed both endothelial dysfunction and aortic stiffening. Results held in vitro, in isolated arteries, and in vivo, positioning fisetin as a promising, clinically translatable intervention for chemotherapy-related cardiovascular toxicity.
