Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1.644 artigos
A natural copper-bound tripeptide extends worm lifespan, improves physical function, and activates two major longevity pathways simultaneously.
Glycoconjugates of carnosine and GHK paired with copper act as SOD mimics and trigger trophic factor release, pointing to new longevity therapies.
Whole transcriptome sequencing uncovers recurrent BEND2 fusions in pancreatic neuroendocrine tumors, independently predicting worse disease-free and disease-specific survival.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
A 303-tumor study shows DNA methylation arrays can classify neuroblastoma into prognostically meaningful subgroups, potentially replacing multiple genomic tests.
A deep learning system measuring thymic health from CT scans reveals that better thymic function predicts longer life and lower cancer and heart disease risk.
Three months of swimming exercise in young mice improved metabolic, cardiovascular, and muscle health deep into old age — but didn't extend lifespan.
Chronic inflammaging silences the epigenetic writer KMT5A in muscle stem cells, erasing H4K20me1 and unleashing ferroptosis—a reversible process.
A microbial sugar molecule leaking from an aging gut selectively expands pre-leukemic blood stem cells, revealing a new therapeutic target.
A 2025 review reveals metformin's multi-pathway potential to slow arterial aging, reduce stiffness, and protect the heart.
Mergulhe abaixo da superfície da via PI3K para entender como mensageiros fosfolipídicos, cascatas de quinases e alças de retroalimentação moldam o equilíbrio entre crescimento e longevidade.
A study of 1.1 million adults shows frailty deficits accumulate in sudden bursts—and these episodes signal sharply higher risk of death and hospitalization.
