Longevity & Aging
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Artigo Científico
24 de mai. de 2026 0
Tema
Reversão do Envelhecimento
Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1.644 artigos
Longevity & Aging
Mitochondria-Targeted Drugs Open New Frontiers Against Brain Aging
A comprehensive review maps the key drug strategies targeting mitochondrial dysfunction in aging and neurodegenerative diseases.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Elamipretide Reverses Heart and Muscle Aging Without Resetting the Biological Clock
A mitochondria-targeting peptide restores cardiac and skeletal muscle function in aging mice—but leaves epigenetic and transcriptomic age unchanged.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Senescent Heart Cells Recruit Killer Immune Cells After Heart Attack via CCL8
P16+ senescent fibroblasts and macrophages hijack immune signaling post-infarction, driving deadly cardiac remodeling through a newly identified CCL8 pathway.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
DLK1 Blocks Muscle Aging Receptor ACVR2B, Not Notch as Long Believed
A crystal structure reveals DLK1 mimics TGF-β ligands to block myostatin signaling, reshaping our understanding of muscle development.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
GLP-1 Drugs Shrink Fat but Also Muscle — New Strategies to Protect Lean Mass
Semaglutide loses ~45% lean mass per kg lost vs. 25% for tirzepatide. Experts weigh interventions to protect muscle in aging patients.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Longer Telomeres Causally Linked to Lower Alzheimer's Risk Through Brain Changes
Mendelian randomization reveals longer telomeres reduce Alzheimer's risk by 16%, with nine brain structural changes partially explaining the link.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
How Your Body Clock Protein CLOCK Controls Aging and Cancer
The circadian CLOCK protein plays a dual role in cellular senescence — supporting healthy aging in normal cells while enabling tumor growth when hijacked.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Key Enzyme TOP3A Found to Control Cancer's Telomere Survival Trick
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Rapamycin Shrinks the Thymus Then Drives It to Rebound Beyond Baseline
Short-term rapamycin causes temporary thymic involution, then triggers regeneration exceeding baseline — hinting at immune rejuvenation as a longevity mechanism.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
How Your Body's Internal Sensing System Shapes the Way You Age
A new review links interoception — the body's ability to sense internal states — directly to aging mechanisms and homeostatic decline.
Artigo Científico
23 de mai. de 2026 0
Longevity & Aging
Scientists Identify Four Stable Immune Personality Types in Healthy Adults
A 2-year study of 100 healthy adults reveals four distinct, stable immunotypes shaped by innate immune activity—not just age, sex, or CMV status.
Artigo Científico
23 de mai. de 2026 0