Oncology, cancer prevention, tumor biology, and immunotherapy relevant to longevity
631 articoli
A new DNA-based treatment blocks the PCSK9 protein, cutting LDL cholesterol by nearly 50% while avoiding common statin side effects.
A large WHO pharmacovigilance analysis reveals which myeloma drugs most strongly signal autonomic, motor, and sensory nerve damage.
Activated T cells release vesicles carrying genomic DNA that reprogram recipient cells to display tumor antigens more effectively.
Fibrotic tissue stiffness activates a cascade that recruits immune cells and generates DNA-damaging aldehydes, linking dense breast tissue to cancer risk.
Phase 1 trial shows MP0317 activates anti-tumor immunity in solid tumors with a favorable safety profile, supporting combination therapy.
RO7300490, a FAP-targeted CD40 agonist, proved manageable in 80 advanced cancer patients but produced no objective tumor responses despite clear immune activation.
A first-in-human trial shows CAR-modified stem cell memory T cells outperform standard CAR T cells in expansion, persistence, and complete responses.
New research shows that the level of RAS oncogene activity determines whether cells become senescent or tumorigenic — a key cancer-prevention insight.
Esplora in profondità i meccanismi molecolari dell'instabilità genomica — dagli stati di crisi indotti dai telomeri e dal rimodellamento epigenetico nelle sedi di rottura del DNA, fino alle più avanzate strategie terapeutiche che prendono di mira la fedeltà della riparazione del DNA nell'invecchiamento e nel cancro.
Scopri cos'è davvero il DNA, come minacce quotidiane come la luce solare e lo stress possono danneggiarlo, e perché proteggere il tuo codice genetico è il segreto per una vita più lunga e in salute.
Zongertinib (Hernexeos) wins FDA approval for unresectable or metastatic HER2-mutant non-squamous NSCLC, expanding targeted therapy options.
A Danish cohort of 49,894 adults shows first-time seizures carry a 76-fold elevated risk of neurological cancer and double the risk of non-neurological cancers within one year.
