Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
2857 articles
A Phase 1b trial shows a daily probiotic capsule may restore immunotherapy response in advanced melanoma patients who had stopped responding.
A 20,000-person study finds IgG glycan patterns track biological aging, predict mortality, and shift toward youth with interventions.
A new GLP-1 therapy engineered to cross the blood-brain barrier enters Phase II trials, targeting cognitive decline in Parkinson's and Alzheimer's.
Ossium Health is banking donor bone marrow for on-demand transplant, targeting immune aging as a future healthspan intervention.
Matter Bio files first IND for Listeria-based therapy targeting pancreatic cancer, merging oncology and longevity science.
A unified mathematical model shows stem cell division rates — not methylation errors — explain why longer-lived species age more slowly.
From refillable eye implants to suprachoroidal injections, next-gen delivery platforms are slashing treatment burden for AMD and diabetic eye disease.
A new PNAS study reveals how mitochondrial free radicals trigger the ATM-CHK2 DNA damage pathway to coordinate three key steps of mitophagy.
Scientists identify a ZBP1-RIPK1 molecular axis that detects oxidized mitochondrial DNA and ignites brain inflammation in Alzheimer's disease.
A muscle-secreted protein boosted by exercise declines with age — restoring it in old mice reverses muscle weakness and bone loss.
Uremic toxins impair mitochondrial cleanup in osteocytes, revealing new drug targets to protect bones in chronic kidney disease.
BioMapAI integrates five omics layers from 249 participants to classify ME/CFS and uncover gut-immune-metabolome drivers of heterogeneous symptoms.
