20 articoli
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Comprehensive review reveals how telomerase biogenesis regulates telomere maintenance, offering new therapeutic targets for aging disorders.
Deep Dive nella biologia dei telomeri, esplorando come la regolazione della telomerasi e le dinamiche del complesso shelterina controllano i percorsi dell'invecchiamento cellulare e della senescenza.
L'RNA telomerasico ingegnerizzato (eTERC) allunga i telomeri nelle iPSC di pazienti e nelle cellule staminali del sangue, offrendo una potenziale terapia per i disturbi della biologia dei telomeri.
Scientists discover a circular RNA that reactivates telomerase enzyme, extending telomeres and reversing aging markers in cells and tissues.
New research reveals hTERT can prevent cellular aging through telomere compaction rather than lengthening, challenging current understanding.
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
A sweeping review maps how telomerase inhibitors evolved from lab concept to approved drug, spotlighting imetelstat's landmark approval in blood cancers.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
Breakthrough imaging reveals how telomerase protects chromosome ends, offering new insights into cellular aging mechanisms.
New structural insights show how telomerase enzymes pair up through H/ACA RNA complexes, advancing our understanding of cellular aging mechanisms.
END-seq rivela che i telomeri dei tumori ALT-positivi condividono le estremità canoniche 5′ ATC con le cellule normali, ma presentano regioni di DNA a singolo filamento in quantità eccezionalmente elevata.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
Gli scienziati hanno sviluppato NU-PRO-1, un PROTAC covalente di nuova generazione che degrada la telomerasi transcriptasi inversa, aprendo potenzialmente la strada al superamento della resistenza nella terapia oncologica.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
Un nuovo studio sui lieviti rivela che i telomeri possono autoregolare la propria lunghezza in modo indipendente tramite il reclutamento di Sir4-telomerasi, ridefinendo la nostra comprensione dell'invecchiamento.
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
A 2025 study shows epitalon lengthens telomeres in normal cells via telomerase and in cancer cells via ALT, offering new anti-aging insights.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
