Longevity & Aging

Single Gut Procedure May Help Keep Weight Off After Stopping Ozempic

Stopping GLP-1 drugs like Ozempic often leads to rapid weight regain — a major obstacle in obesity treatment. Fractyl Health's REVEAL-1 study offers a potential solution: the Revita procedure, a one-time endoscopic treatment targeting the duodenum. Patients who had lost an average of 24% of their body weight on GLP-1 drugs underwent the procedure after stopping medication. One year later, they had retained about 78% of that weight loss. Remarkably, one-third continued losing weight even without medication. The procedure works by remodeling the duodenal lining to restore healthier metabolic signaling around hunger, insulin, and blood sugar. No serious procedure-related adverse events were reported. This could represent a meaningful alternative to lifelong medication dependency for some patients.