Single Amino Acid Difference Reveals How SARS-CoV-2 Evades Human Immunity
A comparative protein interaction map of SARS-CoV-2 and its bat progenitor uncovers the molecular switch behind immune evasion and species barriers.
Autoimmune diseases, immune modulation, inflammation, and self-tolerance
223 Artikel
A comparative protein interaction map of SARS-CoV-2 and its bat progenitor uncovers the molecular switch behind immune evasion and species barriers.
Eine neu identifizierte Immunachse, die CD16+ γδ-T-Zellen und antikörperabhängige Zytotoxizität umfasst, könnte unser Verständnis der immunologischen Kontrolle von HBV grundlegend verändern.
A runaway immune response — not the pathogen itself — drives citrus greening disease, echoing autoimmune mechanisms seen in human illness.
A novel biologic targeting IL-33 shows promising advances in COPD treatment, potentially reshaping how chronic lung disease is managed.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
JAMA publishes a timely review of IgA nephropathy, the leading cause of primary glomerulonephritis worldwide, amid a wave of new therapies.
Nephrologists from Canada and Ireland address clinical questions on IgA nephropathy, one of the most common causes of kidney failure worldwide.
Ein mechanistischer Deep Dive in modernste Anti-Inflammaging-Interventionen – von senolyischer Pharmakologie und präziser Zytokin-Targeting bis hin zu Strategien der partiellen Reprogrammierung, die darauf abzielen, eine jugendliche Immun-Homöostase wiederherzustellen.
Gehen Sie über die Grundlagen des Inflammaging hinaus und verstehen Sie, wie das Altern die Immunzellpopulationen umgestaltet, den SASP auslöst und den Körper auf molekularer Ebene in einen Zustand chronischer niedriggradiger Entzündung versetzt.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
Early influenza infections leave a lasting immunological imprint that determines how your immune system responds to entirely different flu strains later in life.