20 articles
New guidance on using clonal hematopoiesis markers and inherited syndrome testing to evaluate cytopenias and bone marrow failure.
Blood stem cell mutations may actually improve immune checkpoint therapy effectiveness against cancer tumors.
Des mutations des facteurs d'épissage protègent les cellules souches du sang contre le raccourcissement des télomères, révélant un nouveau mécanisme reliant le vieillissement, l'hématopoïèse clonale et le risque de leucémie.
New research explores how naturally occurring aldehydes in our bodies might trigger clonal hematopoiesis, a blood disorder linked to aging.
Une protéomique à grande échelle révèle des profils protéiques plasmatiques distincts associés aux mutations de DNMT3A, TET2 et d'autres gènes de l'hématopoïèse clonale, mettant en lumière les voies inflammatoires impliquées.
New research reveals how thrombopoietin hormone establishes lifelong blood stem cell hierarchy in newborns.
New research reveals how endogenous formaldehyde causes stem cell damage, leading to clonal blood disorders throughout life.
Scientists review how hematopoietic stem cells become senescent with age and identify promising therapeutic strategies to restore blood system function.
A major review outlines how targeted hematologic therapies are transforming outcomes in MGRS, a rare but serious cause of kidney injury.
Scientists identify key molecular pathways that distinguish different types of anemia, opening doors to precision treatments.
Des scientifiques génèrent de véritables cellules souches hématopoïétiques à partir de cellules iPSC humaines, capables de repeupler durablement plusieurs lignées sanguines et rivalisant avec les greffes de sang de cordon.
Researchers identify four LSC subtypes that predict venetoclax resistance and reveal matched subtype-specific therapies for AML patients.
A microbial sugar molecule leaking from an aging gut selectively expands pre-leukemic blood stem cells, revealing a new therapeutic target.
A landmark Nature study shows metformin can suppress the clonal advantage of DNMT3A-mutant blood stem cells, potentially preventing leukemia progression.
New research reveals how age-related blood cell changes may increase pericarditis and myocarditis risk in healthy adults.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity — not just cell diversity — as the core therapeutic target.
New research reveals how aging blood stem cells trigger inflammation and immune dysfunction that accelerates aging throughout the body.
Des scientifiques révèlent comment les lymphomes à double atteinte MYC/BCL2 échappent à la signalisation BCR et identifient de nouvelles cibles thérapeutiques dans ce cancer redoutable.
A landmark multi-omic study maps the full metabolic landscape of human bone marrow stem cells, revealing choline as a key stemness regulator.
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
