Longevity & Aging

New Nanoparticle Clears Brain Amyloid and Restores Memory in Alzheimer's Mice

Researchers developed LRP1-targeted polymersomes that rapidly clear amyloid-β from the brain by modulating blood-brain barrier transport. In Alzheimer's disease mice, this treatment reduced brain amyloid by 45% within 2 hours and restored cognitive function to normal levels for 6 months. The approach works by optimizing receptor trafficking to enhance the brain's natural clearance mechanisms.