Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
368 articles
Penn State researchers found abdominal contractions create pressure waves that gently rock the brain, boosting cerebrospinal fluid flow and waste clearance.
Raising Sox9 levels in aging astrocytes reduced amyloid plaque buildup and protected memory in mouse models with existing Alzheimer's symptoms.
A meta-analysis of 684,493 patients finds just 49% persist with anti-dementia drugs at 12 months, with major variation by drug type and study methodology.
A multi-cohort study finds that every 5 km closer to a lead-releasing facility is tied to measurably lower episodic memory scores.
Plongez dans les mécanismes moléculaires qui sous-tendent la santé cérébrale tout au long de la vie — des cascades de signalisation BDNF-TrkB et de la neurogenèse hippocampique adulte à l'élimination glymphatique de l'amyloïde, en passant par des interventions de pointe incluant les sénolytiques, les agonistes GLP-1 et la stimulation transcrânienne.
Explorez ce qui se passe réellement dans votre cerveau à mesure que vous vieillissez — des réseaux de neurones qui se réduisent aux modifications des substances chimiques cérébrales — et découvrez pourquoi certaines personnes restent mentalement vives bien au-delà de 80 ans.
Blocking the protein PTP1B boosted memory and cleared brain plaque in mice, with potential links to diabetes and obesity treatment.
A 2018 paper on antileukotriene therapy and tau phosphorylation in Alzheimer's mice has been retracted due to image fraud.
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
Leading neurologists argue that amyloid aggregation dynamics may be distorting how we read clinical trial results for Alzheimer's immunotherapies.
A multi-omics subspace-merging algorithm identifies biologically distinct AD subtypes, pointing toward personalized treatment strategies.
