Boosting Astrocyte Sox9 Clears Alzheimer's Plaques and Saves Memory in Mice
Overexpressing Sox9 in brain support cells triggers plaque cleanup and protects cognition in Alzheimer's mouse models.
Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
368 articles
Overexpressing Sox9 in brain support cells triggers plaque cleanup and protects cognition in Alzheimer's mouse models.
A 4-week pilot trial finds nicotinamide riboside boosts cerebrovascular response and cognitive performance in older adults with peripheral artery disease.
New research links early dopamine neuron dysfunction in the entorhinal cortex to memory loss in Alzheimer's — and L-DOPA reversed it in mice.
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
New Nature Medicine research links harmful physical and social exposures to accelerated brain aging, with major implications for dementia prevention.
New single-nucleus and spatial transcriptomics data reveal glial cells—not just neurons—are central players in Alzheimer's disease pathology.
Researchers propose redesigning memory clinic services to match patient complexity with the right level of specialist oversight.
Recent NIA findings spotlight lifestyle factors cutting Alzheimer's risk by 60%, calorie restriction slowing aging, and a gene regulating plaque toxicity.
Maîtrisez l'architecture moléculaire des systèmes glymphatique et lymphatique méningé — des mécanismes de régulation par AQP4 à la thérapie VEGF-C — et explorez les interventions de pointe ciblant ces voies pour la prévention de la neurodégénérescence.
The National Institute on Aging outlines recent priorities in aging and Alzheimer's disease research, including budget planning and training initiatives.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A 10-year Swiss cohort study finds chronic subdural hematoma surgery patients suffer sustained excess mortality and significant cognitive and functional impairments.