Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
368 articles
A formal erratum updates a 2026 cross-sectional survey on mental health factors affecting early-career dementia researchers worldwide.
A key potassium channel, KCNA4, is lost in vulnerable brainstem neurons at Braak II — potentially fueling tau pathology progression.
New research links somatic DNA variants in microglia-like cells to Alzheimer's pathology, opening a novel genetic avenue for disease intervention.
A major Nature Reviews Nephrology analysis reveals uremic toxins, BBB breakdown, and glymphatic failure drive cognitive decline in CKD patients.
New review reveals how glymphatic and meningeal lymphatic dysfunction drive Aβ and tau buildup, and how sleep, surgery, and genetics factor in.
Deleting or inhibiting astrocytic PERK restores the brain's glymphatic drainage system and dramatically reduces Aβ and tau pathology in AD mouse models.
A major meta-analysis reveals DLB incidence rises steeply with age and is higher in men, but widespread underdiagnosis distorts true burden.
A 25-year review of 577 AD vaccine formulations finds only 3 have targeted both Aβ and tau — a major missed opportunity.
A global consortium reveals how tube type, delays, and storage temperature dramatically skew key Alzheimer's blood biomarker readings.
A novel Aβ1-10 peptide vaccine conjugated to carrier proteins reduced plaques, neuroinflammation, and memory deficits in an AD mouse model.
New review links HCMV — infecting up to 100% of adults — to Alzheimer's pathology, tau tangles, and accelerated cognitive decline.
New research reveals APOE2, the longevity-linked gene variant, shields human neurons from aging damage through enhanced DNA repair — not just lipid metabolism.
