574 articles
Un essai clinique financé par le département des Anciens Combattants (VA) a évalué si le médicament antihypertenseur prazosin pouvait éliminer des protéines toxiques associées à l'ECT (encéphalopathie traumatique chronique) et à la maladie d'Alzheimer chez des vétérans de combat.
L'essai de phase 3 de 76 semaines mené par Cassava Sciences sur le simufilam dans la maladie d'Alzheimer a été interrompu, soulevant des interrogations quant à l'avenir de ce médicament.
A 12-month RCT compares three scaffold types and two EDTA concentrations for regenerating necrotic immature permanent teeth.
A completed Columbia University trial compares Family Nurture Intervention in group settings to standard programs for children ages 2–4.5.
A completed Maastricht University trial tests whether pairing NR supplementation with exercise can boost NAD+ levels and reverse metabolic dysfunction in overweight adults.
A landmark Phase I trial of 108 adults tested the first adenovirus-vectored COVID-19 vaccine for safety and immune response.
A phase II trial explores whether the amino acid L-arginine, with or without enzyme inhibitors, can improve erectile function and quality of life after prostate cancer radiation therapy.
The landmark Phase 1/2/3 trial that brought mRNA COVID-19 vaccination to the world, now completed with booster and variant data.
Phase 2 trial explores whether combining oncolytic virus therapy with immunotherapy can rescue patients whose melanoma progressed on PD-1 blockade.
A phase I/II trial tests SV-BR-1-GM, a whole-cell cancer vaccine, combined with the checkpoint inhibitor retifanlimab in patients with metastatic breast cancer.
Researchers at Duke University tested a blood-based biomarker to stratify Alzheimer's patients from healthy adults, aiming to enable earlier detection.
A completed registry study identified and genotyped HoFH patients with LDLR mutations, laying groundwork for targeted gene therapy.
