20 articles
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Comprehensive review reveals how telomerase biogenesis regulates telomere maintenance, offering new therapeutic targets for aging disorders.
Exploration approfondie de la biologie des télomères : comment la régulation de la télomérase et la dynamique du complexe shelterin contrôlent le vieillissement cellulaire et les voies de la sénescence.
L'ARN télomérase modifié (eTERC) allonge les télomères dans les iPSC et les cellules souches sanguines de patients, offrant une thérapie potentielle pour les maladies liées à la biologie des télomères.
Scientists discover a circular RNA that reactivates telomerase enzyme, extending telomeres and reversing aging markers in cells and tissues.
New research reveals hTERT can prevent cellular aging through telomere compaction rather than lengthening, challenging current understanding.
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
A sweeping review maps how telomerase inhibitors evolved from lab concept to approved drug, spotlighting imetelstat's landmark approval in blood cancers.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
Breakthrough imaging reveals how telomerase protects chromosome ends, offering new insights into cellular aging mechanisms.
New structural insights show how telomerase enzymes pair up through H/ACA RNA complexes, advancing our understanding of cellular aging mechanisms.
END-seq révèle que les télomères des cancers ALT-positifs partagent les extrémités canoniques 5′ ATC des cellules normales, mais présentent des régions d'ADN simple brin anormalement abondantes.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
Des scientifiques ont mis au point NU-PRO-1, un PROTAC covalent de premier genre qui dégrade la transcriptase inverse de la télomérase, ouvrant potentiellement la voie au dépassement des résistances aux thérapies anticancéreuses.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
Une nouvelle étude sur la levure révèle que les télomères peuvent autoréguler leur longueur de manière indépendante via le recrutement de la télomérase par Sir4, ce qui transforme notre compréhension du vieillissement.
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
A 2025 study shows epitalon lengthens telomeres in normal cells via telomerase and in cancer cells via ALT, offering new anti-aging insights.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
