Insulin resistance, blood sugar regulation, metabolic syndrome, and body composition
409 articles
A 5-year study finds bariatric surgery offers meaningful but attenuated weight loss in PWS kids versus lifestyle intervention alone.
A large real-world study finds post-transplant diabetes requiring insulin marks a high-risk metabolic phenotype with far worse graft and patient outcomes.
A Phase IIa trial explores whether the HIF-PHI drug daprodustat can safely replace EPO injections in hemodialysis patients with anemia.
A newly identified mechanism shows how omega-3 fatty acids protect aging kidneys — and why low FFAR4 receptor expression accelerates kidney disease.
New JAMA research suggests reducing dietary protein may slow kidney disease progression and improve patient outcomes.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
Blocking mTOR forces cancer cells to rewire cholesterol uptake and transport, revealing new drug targets when combined with rapamycin.
Scientists identify MOXD1 as a driver of MASH and show blocking it with a small molecule reverses liver fat accumulation in mice.
A 6-month AI-driven personalized diet intervention cut BMI by 33% and reduced biological age by 8 years in morbidly obese patients.
A sweeping review of GLP-1 agonists, tirzepatide, and emerging hormone combos reshaping obesity treatment in 2025.
The TRIUMPH program tests retatrutide across 5,800+ patients using a novel basket trial design to simultaneously tackle obesity and its complications.
Une plongée en profondeur au niveau moléculaire dans la cinétique de formation des AGE, les isoformes de RAGE, les réseaux transcriptionnels en aval et les interventions fondées sur des preuves — pour ceux qui souhaitent une compréhension mécanistique complète.
