Autoimmune diseases, immune modulation, inflammation, and self-tolerance
219 articles
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
JAMA publishes a timely review of IgA nephropathy, the leading cause of primary glomerulonephritis worldwide, amid a wave of new therapies.
Nephrologists from Canada and Ireland address clinical questions on IgA nephropathy, one of the most common causes of kidney failure worldwide.
Une analyse mécanistique approfondie des interventions anti-inflammaging de pointe — de la pharmacologie sénolytique et du ciblage précis des cytokines aux stratégies de reprogrammation partielle visant à restaurer l'homéostasie immunitaire juvénile.
Allez au-delà des bases de l'inflammaging pour comprendre comment le vieillissement remodèle les populations de cellules immunitaires, déclenche le SASP et maintient l'organisme dans un état d'inflammation chronique de bas grade au niveau moléculaire.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
Early influenza infections leave a lasting immunological imprint that determines how your immune system responds to entirely different flu strains later in life.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
A new in vitro study shows Thymosin α1 triggers dendritic cells to release IL-15, boosting CD8+ T cell killing and reducing HIV reservoir size.
A clinical case from Japan illustrates how cryoglobulinemia can drive membranoproliferative glomerulonephritis, a serious kidney complication.
A major review maps emerging immunotherapies—from JAK inhibitors to microbiome interventions—that could transform care for celiac and food allergy patients.
