Autoimmune diseases, immune modulation, inflammation, and self-tolerance
219 articles
New research reveals that mitochondrial energy pathways directly govern dendritic cell immune activation, with major implications for cancer and autoimmune therapies.
Mice lacking the PERP apoptosis gene develop faulty thymic immune screening, accumulating self-reactive T-cells that trigger arthritis as they age.
Pyruvate, a core metabolic molecule, suppresses interferon signaling by directly modifying STAT1 — linking metabolism to immune control.
A bibliometric analysis of 7,037 studies reveals gut microbiota, fibroblast-like synoviocytes, and biologic therapy as the emerging frontiers in RA immunology.
New biomarker in joint tissue correlates with inflammation severity and may explain why some patients don't respond to corticosteroids.
Specialized immune cells use antibodies to kill hepatitis B-infected cells, offering new targets for viral cure strategies.
Breakthrough immunotherapy approach demonstrates effectiveness in treating multiple autoimmune conditions simultaneously.
Groundbreaking study reveals how B cells acquire mutations in checkpoint genes to bypass immune tolerance in autoimmune thyroid disease.
International study of 1,200+ patients identifies clinical factors that predict sight-threatening complications in uveitis.
New research reveals how hepatitis B virus hijacks cellular machinery to suppress interferon signaling and evade immune detection.
New research reveals how fat tissue activates T cells, potentially explaining the link between obesity and inflammatory joint disease.
Icotrokinra, a breakthrough oral peptide targeting IL-23, demonstrates significant skin clearance in psoriasis with sustained benefits through 52 weeks.
