5007 articles
Newly characterized lipid mediators derived from DHA may defend against Alzheimer's, Parkinson's, stroke, and macular degeneration.
A comprehensive review reveals how transsulfuration pathway products and H₂S-donors may offer new therapeutic avenues for hyperhomocysteinemia.
NAC-coated molybdenum disulfide quantum dots target kidney mitochondria, simultaneously neutralizing ROS and restoring depleted antioxidant enzymes in AKI models.
The TCA cycle is a central metabolic hub linking energy production, amino acid synthesis, and cholesterol regulation — all critical to aging biology.
A phase 2 trial finds tesamorelin reduces abdominal obesity in virally suppressed HIV patients but shows no significant cognitive improvement.
A case report reveals MK-677, a widely used growth hormone secretagogue, triggered significant liver damage in a healthy man in his 30s.
Scientists created stem cell models of Wiedemann-Rautenstrauch syndrome, uncovering how POLR3A mutations disrupt nucleoli and trap telomerase RNA.
A comprehensive 2025 review charts the signaling pathways, drug targets, and emerging strategies scientists are using to slow human aging.
A systematic review reveals how bioactive food compounds modulate telomerase activity to potentially prevent hepatocellular carcinoma.
A 2025 review maps the most promising drug targets and novel strategies—from gene therapy to gut microbiome interventions—for treating MASH.
A new open-access lipidomics database reveals how cholesterol dysregulation in astrocytes may drive Alzheimer's neuroinflammation.
A 2025 JCI review maps nonopioid analgesic targets across inflammatory, neuropathic, and nociplastic pain, spotlighting ion channels, GPCRs, and emerging gene therapies.
