Ketamine's Antidepressant Secret Unlocks New GPCR Drug Targets
Researchers decoded how ketamine fights depression via opioid receptors, revealing a roadmap to safer, more targeted antidepressants.
446 articles in this topic
Researchers decoded how ketamine fights depression via opioid receptors, revealing a roadmap to safer, more targeted antidepressants.
A randomized trial finds intra-arterial alteplase after successful thrombectomy does not improve outcomes in posterior circulation stroke.
A Danish double-blind RCT tests a novel at-home electromagnetic field headband against sham for moderate-to-severe depression over 8 weeks.
A 4-week pilot trial finds nicotinamide riboside boosts cerebrovascular response and cognitive performance in older adults with peripheral artery disease.
New research links early dopamine neuron dysfunction in the entorhinal cortex to memory loss in Alzheimer's β and L-DOPA reversed it in mice.
Somatic mutations found in cancer driver genes accumulate in Alzheimer's brain macrophages, potentially driving the neuroinflammation that accelerates disease.
Stanford-led framework defines the five core components of medical digital twins and maps how AI plus mechanistic modeling can create living patient simulations.
New Nature Medicine research links harmful physical and social exposures to accelerated brain aging, with major implications for dementia prevention.
A secondary analysis of the ARCADIA trial finds that high-risk hypertension features eliminate the benefit of anticoagulation over aspirin in cryptogenic stroke patients.
New single-nucleus and spatial transcriptomics data reveal glial cellsβnot just neuronsβare central players in Alzheimer's disease pathology.
A randomized pilot study finds PEMF therapy significantly improved fatigue, sleep, depression, and walking capacity in post-COVID-19 patients over 5 weeks.
A landmark review reveals the ANS regulates metabolism, immunity, and aging β far beyond simple fight-or-flight control.