5061 articles
New research reveals melatonin rescues the brain's glymphatic system after sleep restriction by restoring a critical water channel protein.
A multi-biomarker study finds pwMS show accelerated thymic involution, senescent T cell expansion, and neuroinflammation linked to aging.
Orally bioavailable cyclin A/B RxL inhibitors exploit a cell-cycle vulnerability in small-cell lung cancer and other G1-S-checkpoint-deficient tumors.
A 12-week randomized trial finds krill oil boosts plasma EPA and DHA roughly 1.5× more than equivalent fish oil doses.
A Swedish cohort of 4.3 million found maternal diabetes during pregnancy significantly increases offspring CVD risk, with pregestational diabetes driving the highest hazard.
A pathological study ties common Lp(a) risk gene variants to specific coronary thrombosis morphologies in sudden cardiac death victims.
A surprising structural feature on axon initial segments lets excitatory synapses jump-start neuron firing and redirect brain circuit information flow.
A comprehensive review reveals how the enzyme CD38 drives cardiovascular and neurological disease through calcium, NAD+, and inflammation signaling.
Chronic NAD depletion causes mitochondrial DNA to escape into the cytoplasm, activating an interferon response that mimics a viral infection.
A novel immune cell subset, CD38-high monocytes, spikes within 24 hours of sepsis onset and may serve as both a diagnostic marker and drug target.
A specialized immune cell population near adipose nerves declines with age, fueling inflammaging and disrupting fat metabolism.
Cholecystokinin prevents microglia from pruning excitatory synapses in sepsis brain injury, pointing to new cognitive protection strategies.
