444 articles in this topic
Specific AQP4 genetic variants alter glymphatic drainage efficiency, directly influencing motor symptom severity and progression in early Parkinson's disease.
New mouse study reveals aging causes region-specific neuroinflammation and perineuronal net accumulation linked to memory decline.
A landmark multicohort proteomics study reveals how APOE2 and APOE4 shape Alzheimer's risk through entirely distinct molecular mechanisms.
New research shows single V1 neurons in the visual cortex track internal arousal states, directly predicting perception and reaction speed.
New research reveals how the brain selectively triggers learning only during meaningful errors — not random neural noise.
A landmark Nature Neuroscience study reveals how peripheral immune cells infiltrate the spinal cord in ALS, pointing to targeted immunotherapy.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
Scientists used stem cell-derived vesicles to deliver light-activated gene therapy to the brain without surgery, reversing cognitive decline in Alzheimer's mice.
A bibliometric analysis of 595 papers maps how glymphatic-Alzheimer's research has grown exponentially, pinpointing AQP4, sleep, and DTI-ALPS imaging as the hottest frontiers.
Cerebral hypoperfusion drives glymphatic dysfunction in systemic inflammation — and restoring blood flow with levosimendan reverses it.
HIE disrupts the glymphatic system in neonatal brains, impairing waste clearance and development with lasting consequences.
