5061 articles
A mitochondria-derived peptide activates the Nrf2 antioxidant pathway to block cartilage breakdown and inflammatory cell death in osteoarthritis.
A comprehensive review reveals how elamipretide binds cardiolipin in the inner mitochondrial membrane, restoring bioenergetics in aging and disease.
MOTS-c, a peptide encoded in mitochondrial DNA, declines with age and may prevent ฮฒ-cell senescence to delay both type 1 and type 2 diabetes.
MOTS-c enters cell nuclei during oxidative stress to activate antioxidant genes, protecting lungs during cardiac surgeryโand predicting ARDS risk.
A 533-patient Chinese RCT finds adding LMWH to insulin doesn't reduce organ failure or death in hypertriglyceridemic acute pancreatitis.
A phase 2 trial finds certolizumab pegol added to standard care reduced severe pregnancy complications in high-risk APS patients to just 20%.
A 38-plex imaging study reveals how microglia shift along a continuous activation spectrum in Alzheimer's disease, with key protein changes in CA1.
A new systematic review finds creatine linked to cognitive benefits in older adults, especially memory and attention, though high-quality trials are still needed.
A landmark Swedish cohort tracked 427 people from age 16 to 63, revealing peak fitness arrives in the 20sโ30s, then fades โ mirroring elite athletes.
A comprehensive review confirms that regular exerciseโacross all modalitiesโdramatically reduces chronic disease risk and extends healthspan.
Scientists identify Pannexin1 as a calcium leak channel in the ER that triggers cellular senescence and kidney scarring after acute injury.
A landmark theory proposes that tumor suppression mechanisms like cellular senescence inadvertently accelerate aging by restricting tissue renewal.
