290 articles in this topic
A leading expert argues that success in obesity pharmacotherapy must now be measured by cardiometabolic health outcomes, not just pounds lost.
A comprehensive 2025 review maps the metabolic chaos driving diabetic foot ulcers and evaluates emerging treatments from exosomes to gene therapy.
A novel mathematical model using deuterium MRI shows gastric bypass redirects nearly all ingested glucose through the liver, with more peripheral disposal.
A comprehensive 2025 review framework matches GLP-1 agonists, tirzepatide, and other AOMs to specific obesity phenotypes, complications, and life stages.
A 60-week RCT finds semaglutide 2.4 mg sustains ~240 kcal/day reduction even after appetite benefits diminish.
50 nm polystyrene nanoplastics accumulate in mouse testes, degrading sperm quality and triggering iron-dependent cell death through a newly identified mitochondrial pathway.
An erratum to a 2022 Cell Metabolism paper describing a bone marrow lipolytic factor that links mechanical force to bone formation and lymphocyte production.
A new perspective argues sedentary behavior independently impairs insulin sensitivity and metabolic function, upstream of obesity itself.
A newly discovered liver-to-gut communication pathway shows how fatty liver worsens hyperglycemia by hijacking intestinal stem cell behavior.
New research reveals FGF21 has a physiological role in reducing ER stress by amplifying the unfolded protein response through sulfide signaling.
Scientists identify an NADH-dependent molecular switch linking glycolysis to mitochondrial ATP synthesis, revealing a new metabolic control point.
A genomic study of 3,358 biopsy-proven MASLD patients finds APOB pathogenic variants linked to significantly higher steatosis and liver injury scores.
