Metabolic Health
Pyruvate Directly Rewrites Your Epigenome When Blood Sugar Spikes
A new PTM called lysine pyruvylation links glycolytic activity directly to gene regulation, with SIRT3 acting as the eraser.
Research Paper
Jul 5, 2026 0
All Articles
6,382 articles
Brain Health
Brain Shrinkage and White Matter Damage Together Predict Cognitive Decline
A new index combining brain atrophy, white matter lesions, and cognition reveals who maintains brain health with age — and who doesn't.
Research Paper
Jul 5, 2026 0
Exercise & Fitness
Ginsenoside Rg1 Doubles Muscle Stem Cells in Older Women After Resistance Training
A small but rigorous crossover trial shows a ginseng compound dramatically boosts muscle stem cells and mitochondrial content in women over 60.
Research Paper
Jul 5, 2026 0
Longevity & Aging
High Phosphate Diets Drive Hypertension by Hijacking Brain Growth Factor Signaling
Excess dietary phosphate raises FGF23, which crosses into the brain and triggers sympathetic overactivation and high blood pressure via FGFR4.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Hyperphosphatemia Explained: How Excess Phosphate Disrupts Your Body
A comprehensive review of hyperphosphatemia covers phosphate physiology, hormonal regulation, and clinical consequences for aging and kidney health.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Klotho Protein Emerges as Key Link Between Aging and Insulin Resistance
New review reveals how declining Klotho levels drive insulin resistance and type 2 diabetes, positioning this anti-aging protein as a potential biomarker.
Research Paper
Jul 4, 2026 0
Longevity & Aging
High Cardiorespiratory Fitness Cuts Multimorbidity Risk by 21% Over 15 Years
A UK Biobank study of 38,000+ adults finds that high fitness delays the onset of multiple chronic diseases by over a year.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Heart Failure Slashes Exercise Capacity in Older Adults and Worsens With Age
A meta-analysis of 38 studies reveals older heart failure patients have dramatically lower peak oxygen uptake than controls, declining further with each decade.
Research Paper
Jul 4, 2026 0
Longevity & Aging
VO₂max Is Your Longevity Engine — Here's Why Fitness Predicts How Long You Live
Cardiorespiratory fitness independently predicts morbidity and mortality. Danish review explains why VO₂max may be your most important health metric.
Research Paper
Jul 4, 2026 0
Longevity & Aging
VO2 Max Is the Strongest Longevity Predictor — Here's the Optimal Exercise Dose
A landmark review maps the dose-response curve between cardiorespiratory fitness and mortality, revealing J-shaped risks at exercise extremes.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Plant Compound Celastrol Clears Senescent Cells and Extends Lifespan in Animal Models
Celastrol outperforms leading senolytics by targeting the Hsc70-Bim protein complex, clearing zombie cells and reducing organ fibrosis in mice and flies.
Research Paper
Jul 4, 2026 0
Hormones
Primary Aldosteronism Severity Score Predicts Treatment Success After Surgery or Medication
A new severity classification for primary aldosteronism reliably predicts lateralization and how well patients respond to treatment.
Research Paper
Jul 4, 2026 0