446 articles in this topic
A machine-learning model using 39 cardiovascular and autonomic variables predicted cognitive test performance with ~71% accuracy in healthy adults.
A 38-year Finnish cohort study finds higher lifelong physical activity protects information processing and working memory into midlife.
A new Cell study reveals the fronto-insular circuit as the key mediator of TMS antidepressant effects, opening the door to optimized treatment.
New iPSC and cerebral organoid research shows HSV-1 directly activates neurodegeneration and senescence pathways, supporting the viral hypothesis of Alzheimer's disease.
Plasma p-tau217 accurately detects preclinical Alzheimer's in cognitively normal adults, potentially enabling earlier intervention.
A phase 2 RCT finds ABvac40, a vaccine targeting vascular amyloid-ฮฒ40, is safe and immunogenic in early Alzheimer's patients with no ARIA-E.
ฮฒ-endorphin released during exercise wraps around toxic Aฮฒ aggregates, forming a 'corona' that shields brain cells from Alzheimer's damage.
A 19-year cohort study maps how amyloid and tau shift in CSF across the full Alzheimer spectrum, pinpointing the optimal intervention window.
New research overturns assumptions: dolichoectasia, not stenosis, strongly predicts lacunar stroke and cerebral small-vessel disease progression.
A 79-year-old man developed involuntary movements weeks after carotid surgery, revealing a rare stroke complication.
A multinational study finds 56% of genetically diagnosed infants with epilepsy have variants potentially amenable to antisense oligonucleotide treatment.
A newly identified glucocorticoid-iron-ฮฑ-synuclein axis drives anxiety-linked brain changes, opening fresh therapeutic targets.
