562 articles in this topic
Genetic variants in the water channel gene AQP4 directly affect brain volume and cognition — and interact with sleep to accelerate Alzheimer's progression.
New research in Cell maps the fronto-insular circuits behind accelerated TMS, potentially transforming rapid depression treatment.
New spatiotemporal mapping of the human meninges exposes how immune cells and brain barriers co-develop from 6–23 gestational weeks.
A new genetic tracing system reveals the brain's waste-clearance routes are compartmentalized, rapid in some areas, and disrupted differently by inflammation vs. amyloid.
A neuron-specific proteasome system governs tau pathology, with APOE4 carriers showing heightened vulnerability as this system declines with age.
A new Nature Neuroscience study reveals an unexpected molecular mechanism that initiates tau aggregation, the hallmark of Alzheimer's disease.
Scientists built human amygdala-like brain organoids that model stress circuitry, uncovering a novel cortisol-driven mechanism tied to primate-specific gene regulation.
A chromatin-remodeling gene called SMARCAD1 controls tau levels — and switching it off could be a new therapeutic target for Alzheimer's.
A newly identified proteasome activator, PA200, clears toxic alpha-synuclein aggregates and maintains function even when standard protein-disposal systems fail.
A JAMA Insights review breaks down how hearing aids work, their limits, and whether OTC devices stack up against prescription options.
Researchers respond to critiques of their trial showing positive airway pressure therapy may improve cognitive outcomes in Parkinson's disease.
New mouse study reveals why women face higher Alzheimer's risk — local brain estrogen deficiency triggers age-specific memory loss and ECM remodeling.
