Two Gene Variants Combine to Trigger Earlier Diabetes Onset in Rare Family Study
A Japanese family case reveals how inherited HNF1A and ABCC8 mutations act additively to accelerate early-onset diabetes beyond either variant alone.
290 articles in this topic
A Japanese family case reveals how inherited HNF1A and ABCC8 mutations act additively to accelerate early-onset diabetes beyond either variant alone.
A newly identified mitochondrial NAD transporter in fat cells controls whether you develop obesity and insulin resistance as you age.
A newly discovered amygdala–liver neural circuit drives stress hyperglycemia independently of cortisol or adrenaline — and chronic stress breaks it.
New research reveals pulsed electromagnetic field therapy selectively enhances ATP-linked mitochondrial respiration, pointing to a specific cellular energy mechanism.
A steroid hormone activates receptor GPR56 to block ferroptosis, a form of iron-driven cell death linked to liver disease.
A large Japanese cohort study shows polygenic risk scores predict T2D onset, yet exercise and metabolic health blunt even high genetic risk.
FTO demethylase in AgRP neurons alters Kif1a splicing to boost neuropeptide release, promoting weight gain in mice.
New research argues shared household metabolic factors — not just intrauterine exposure — drive MASLD risk in offspring.
New research reveals oxytocin signals fat cells to release lipids for milk, reshaping our understanding of lactation biology.
New composite biomarker combining inflammation, nutrition, and immunity markers shows promise for cardiovascular risk assessment.
New research reveals how RAP1A protein regulates liver blood vessel function and may influence fibrosis progression in chronic liver disease.
New research reveals how mitochondrial metabolism regulates dendritic cells' ability to activate anti-tumor immunity.