17 articles
Calcium alpha-ketoglutarate rescues memory-related synaptic plasticity in Alzheimer's mice, pointing to a geroprotective supplement as a potential AD therapy.
A study of 4,260 health enthusiasts found delayed-release calcium-AKG was associated with measurably younger epigenetic age.
The TCA cycle is a central metabolic hub linking energy production, amino acid synthesis, and cholesterol regulation β all critical to aging biology.
Ξ±KG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
A subpopulation of intestinal stem cells enriched for old mitochondria produces more Ξ±-ketoglutarate, driving Paneth cell regeneration and tissue niche renewal.
A TCA cycle metabolite reshapes immune responses through epigenetic and covalent mechanisms, opening doors for cancer and autoimmune therapies.
A TCA cycle metabolite reprograms inflammatory macrophages after myocardial infarction, revealing a novel metabolite-epigenetic therapeutic pathway.
Researchers mapped how anesthetics, nitric oxide, and other drugs alter hemoglobin's grip on oxygen β with real implications for critical care.
A longitudinal mouse study identifies sex-specific plasma metabolite biomarkers of frailty, pointing to B vitamins in females and lipids in males.
A leading aging researcher audits NMN, urolithin A, spermidine, and more β revealing what actually works and what falls short.
A new viewpoint challenges the '900-day rule' in aging research, arguing that healthspanβnot just lifespanβmust be geroscience's primary target.
New research reveals how Ξ±-ketoglutarate regulates AMPK synthesis, offering potential cancer therapy targets through energy stress.
