Stanford Discovers Protein Traffic Jams Drive Brain Aging and Alzheimer's Risk
Stanford researchers found ribosome stalling in aging brain cells triggers faulty proteins and toxic clumps linked to Alzheimer's disease.
20 articles
Stanford researchers found ribosome stalling in aging brain cells triggers faulty proteins and toxic clumps linked to Alzheimer's disease.
Arginine supplements reduced toxic amyloid buildup, brain inflammation, and behavioral decline in fly and mouse Alzheimer's models.
Scientists discover tanycytes help clear toxic tau from the brain. When damaged, these cells may allow Alzheimer's progression.
Raising Sox9 levels in aging astrocytes reduced amyloid plaque buildup and protected memory in mouse models with existing Alzheimer's symptoms.
Buck Institute finds the longevity-linked APOE2 variant shields neurons from DNA damage and cellular senescence, explaining its Alzheimer's protection.
New mouse research finds the trendy D+Q senolytic combo severely damages myelin, raising red flags for longevity self-experimenters.
Researchers created modified psilocin that maintains antidepressant effects while dramatically reducing psychedelic side effects in mice.
UC Davis scientists created novel brain-healing molecules that activate key serotonin receptors tied to neuroplasticity โ without triggering hallucinations.
Researchers identified the gene that transports queuosine, a micronutrient crucial for brain health and cancer defense, solving a decades-old mystery.
A small trial found tocilizumab, an anti-inflammatory drug, cut depression remission rates better than SSRIs by targeting IL-6, not brain chemistry.
Declining Menin in the hypothalamus drives inflammation and aging. Restoring it reversed decline; D-serine amino acid improved cognition in mice.
Astrocytes, once thought passive, actively control fear memories in the brain, opening new paths for anxiety disorder treatments.
The SenNet atlas reveals where aging cells accumulate in human tissues, opening new doors for senolytic therapies and healthspan extension.
A 12-week clinical trial found older adults taking probiotics with antidepressants had greater reductions in depression and anxiety than placebo.
New compounds targeting the cPLA2 enzyme may reduce Alzheimer's-linked brain inflammation, especially in high-risk APOE4 gene carriers.
Comprehensive analysis reveals whole dietary patterns, not individual supplements, show strongest links to reduced depression in adolescents.
MIT's self-organizing laser creates ultra-sharp brain images 25x faster, enabling real-time tracking of drugs crossing the blood-brain barrier.
Researchers turned ordinary brain cells into plaque-clearing machines, reducing Alzheimer's amyloid by half in mice with one treatment.
Researchers discover toxic protein pair that kills brain cells in Alzheimer's and develop compound to block it in mice.
UCLA scientists discover why some neurons resist Alzheimer's better than others, revealing a natural protein cleanup system that could lead to new treatments.