Pfizer's PCSK9 Inhibitor Bococizumab Put to the Test in High-Risk Hyperlipidemia
A Phase 3 trial examines whether bococizumab slashes LDL in statin-treated patients at elevated cardiovascular risk.
20 articles
A Phase 3 trial examines whether bococizumab slashes LDL in statin-treated patients at elevated cardiovascular risk.
Phase 3 trial of IBI306, a PCSK9 inhibitor, tests LDL-C reduction in Chinese adults with high cardiovascular risk on statin therapy.
Revolutionary nanobody drug targets two proteins simultaneously, achieving complete tumor elimination in preclinical studies.
New oral drug MK-0616 matches injectable PCSK9 inhibitors for lowering LDL cholesterol while offering patient-friendly pill form.
Breakthrough study shows one epigenetic factor can transform cardiac fibroblasts into heart muscle cells, improving function after myocardial infarction.
New study shows PCSK9 monoclonal antibodies dramatically reduce cardiovascular events and hospitalizations in very high-risk patients.
A correction to a landmark study linking breast cancer to latent BMPR2-driven pulmonary hypertension susceptibility in Circulation.
Advanced cholesterol-lowering therapies show promise for dramatically reducing cardiovascular disease risk through innovative approaches.
A completed Phase IIIb trial tests whether pelacarsen can safely lower Lp(a) in historically underrepresented cardiovascular disease populations.
A comprehensive review reveals tirzepatide improves blood pressure, lipids, liver fat, kidney function, and slashes 10-year cardiovascular risk by up to 23.5%.
New research reveals how eliminating urokinase plasminogen activator can temporarily protect against diet-induced weight gain and metabolic dysfunction.
Breakthrough discovery of PAK1 kinase activators shows promise for treating cardiac hypertrophy and heart failure through targeted enzyme enhancement.
Laroprovstat, a once-daily pill, slashed LDL by 80% when combined with rosuvastatin โ rivaling injectable PCSK9 inhibitors.
SHR-1918 antibody dramatically reduced LDL cholesterol in patients with severe genetic hypercholesterolemia through novel pathway.
The first disease-specific treatment for Barth syndrome gains FDA accelerated approval, targeting mitochondrial dysfunction to restore muscle strength.
A muscle enzyme that declines in heart attack patients may hold the key to preserving cardiac function after MI.
A 330-patient multicenter RCT tests whether thymosin ฮฑ1 can curb immune dysregulation and organ dysfunction after acute type A aortic dissection repair.
A post hoc analysis of the CLEAR Outcomes trial finds bempedoic acid significantly reduces DVT and pulmonary embolism risk.
Meta-analysis shows recaticimab dramatically reduces LDL cholesterol and other cardiovascular risk markers with manageable side effects.
Amgen's siRNA therapy olpasiran targets lipoprotein(a), a stubborn cardiovascular risk factor with no approved treatments.