Fatty Acid Molecule Erucamide Halts Retinal Degeneration in Mice
A naturally occurring fatty acid amide activates immune cells in the retina, protecting neurons and blood vessels from degenerative damage.
20 articles
A naturally occurring fatty acid amide activates immune cells in the retina, protecting neurons and blood vessels from degenerative damage.
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
Dopamine agonist pramipexole significantly reduced depression symptoms when added to standard antidepressants in resistant cases.
Emerging mycotoxin found in foods crosses blood-brain barrier, disrupts neurotransmitters and impairs cognitive function in animal model.
DPCPX treatment enhanced neurogenesis and improved motor/memory function in stroke recovery studies using advanced PET imaging.
Researchers built a machine learning imaging pipeline to detect cerebral microhemorrhages and tested SS-31 (elamipretide) in aged hypertensive mice.
Scientists develop pathway-selective drug that activates beneficial brain receptors while avoiding negative feedback loops.
A 5-year cohort study finds elevated blood palmitoleic acid โ a marker of excess energy intake โ accelerates brain hypometabolism linked to cognitive decline.
Researchers discover a phospholipid derivative that protects brain cells by calming overactive immune cells in dementia-prone mice.
ฮฒ-endorphin released during exercise wraps around toxic Aฮฒ aggregates, forming a 'corona' that shields brain cells from Alzheimer's damage.
A Danish double-blind RCT tests a novel at-home electromagnetic field headband against sham for moderate-to-severe depression over 8 weeks.
AI-driven study identifies ฮฑ-amyrin from fruits and vegetables as a promising Alzheimer's treatment that protects mitochondria and reduces tau tangles.
Indole compounds from gut microbes reduce meth-induced depression and anxiety through brain receptor signaling.
A validated UPLC-MS/MS method analyzing 566 plasma samples reveals key patient factors that explain why standard antidepressant doses fail many people.
NMDA receptor antagonist memantine restored social and recognition memory deficits caused by chronic methamphetamine exposure.
MRI study reveals disrupted neurotransmitter balance in periaqueductal gray of chronic low back pain patients, potentially explaining treatment resistance.
A 4-week pilot trial finds nicotinamide riboside boosts cerebrovascular response and cognitive performance in older adults with peripheral artery disease.
A multicenter RCT in JAMA Neurology finds electroacupuncture nearly doubles responder rates vs sham for chronic shingles nerve pain.
A ยต-opioid receptor superagonist shows strong analgesic potency in preclinical work while minimizing addiction, respiratory depression, and other classic opioid harms.
A lab study finds ACU193 binds less to brain blood vessels than lecanemab, potentially explaining differences in ARIA side effect risk.