20 articles
New research reveals how the cholesterol medication bempedoic acid directly activates PPARΞ±, boosting fat metabolism beyond its known effects.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Breakthrough study reveals sepiapterin dramatically outperforms existing PKU therapy, offering hope for better metabolic control.
A landmark 500-patient RCT finds sodium bicarbonate offers no benefit over placebo for critically ill adults with metabolic acidosis and shock.
A landmark RCT shows finerenone reduces eGFR decline and kidney-cardiovascular events in CKD patients without diabetes.
Veterinary sedative medetomidine increasingly adulterates street fentanyl, causing severe cardiac effects and heightened overdose risk.
Ketone body Ξ²-OHB prevents sepsis-induced liver damage by modifying antioxidant enzyme SOD2, offering new therapeutic approach.
Sodium propionate reduced liver inflammation and fat accumulation in diabetic mice fed high-fat, AGE-rich diets through multiple protective mechanisms.
Meta-analysis of 106,395 patients reveals GLP-1 receptor agonists increase risk of gallstones by 46% and GERD by 119%.
Natural polyketide from marine bacteria enhances cholesterol removal and improves fat metabolism in liver cells and mice.
Novel GLP-1 analogue NNC5840 achieves greater weight reduction than semaglutide by optimizing receptor signaling bias rather than potency.
New research reveals semaglutide's liver benefits work independently of weight loss through specialized liver blood vessel cells.
Scientists identify how a metabolic enzyme drives kidney inflammation in diabetes, opening doors for targeted therapies.
Prolactin-releasing peptide analog promotes sustained fat burning for weight loss, offering new approach beyond appetite suppression.
A comprehensive 2025 review framework matches GLP-1 agonists, tirzepatide, and other AOMs to specific obesity phenotypes, complications, and life stages.
Researchers create user-friendly platform that predicts which compounds could become effective obesity treatments.
Daily anthocyanin supplementation helped over half of prediabetic participants return to normal glucose tolerance in just 12 weeks.
New research reveals pulsed electromagnetic field therapy selectively enhances ATP-linked mitochondrial respiration, pointing to a specific cellular energy mechanism.
Advanced incretin-based therapies show potential for major weight loss while protecting heart, kidney, liver, and brain health.
Analysis of 137,451 reports shows GLP-1 drugs linked to unexpected side effects beyond known gastrointestinal issues.
