20 articles
A comprehensive review maps berberine's multi-target mechanisms across cancer, neurological, cardiovascular, and metabolic diseases.
A 10-year review reveals berberine, from the herb Coptidis Rhizoma, fights cancer through apoptosis, autophagy, and gut microbiota modulation.
A comprehensive 2025 review maps berberine's multi-target anti-obesity mechanisms, clinical trial evidence, and strategies to overcome its poor bioavailability.
A 6-year follow-up of a Chinese RCT shows berberine reduced colorectal adenoma recurrence from 52% to 35% even after stopping the drug.
A new study reveals gut microbes convert berberine into dihydroberberine, which blocks a serotonin pathway to protect against cholestatic liver disease.
A natural compound used in traditional Chinese medicine may offer a new treatment for androgenetic alopecia by activating the Wnt/Ξ²-catenin signaling pathway.
Study reveals berberine prevents diabetic kidney disease through Nrf2 pathway activation and ferroptosis inhibition.
Combining two traditional herbal compounds fixes a dangerous liver toxicity problem while making colitis treatment significantly more effective.
Reverse network pharmacology pinpoints berberine as a promising treatment for CKM syndrome, validated in a novel mouse model combining metabolic and cardiac stress.
Berberine suppresses ISG15 and pyroptosis to reduce kidney inflammation and fibrosis in diabetic kidney disease, revealing a novel therapeutic mechanism.
A natural alkaloid from traditional Chinese medicine activates a key bile acid receptor to restore intestinal balance and reduce colitis inflammation.
Combining metformin and berberine outperforms either drug alone in reversing NAFLD by powerfully activating the AMPKβSREBP1βFASN lipid-regulation axis.
A traditional Chinese medicine duo β skullcap root and goldthread β reduces fatty liver by simultaneously boosting fat burning and blocking fat synthesis.
Bioinspired hydrogel microspheres co-delivering berberine and bone-promoting stem cells eradicate resistant bacteria, quell inflammation, and rebuild bone.
Coptisine targets the STAT1/IRF1/GPX4 axis to halt ferroptosis in Kupffer cells, reducing sepsis-driven liver damage in mice and cell models.
Dendrobium officinale extract protects aging kidneys by activating antioxidant defenses through a key cellular signaling pathway.
Liensinine shifts liver cancer cells from glycolysis to oxidative phosphorylation via AMPK-HIF-1Ξ±, reshaping the tumor immune microenvironment.
Buddleoside activates AMPK, suppresses MTORC1, and restores autophagy to combat nonalcoholic steatohepatitis in mice.
Gastrodia elata extract and its compound Parishin E restored memory function and reduced toxic protein buildup in Alzheimer's disease models.
Erzhi Pill, a traditional Chinese medicine, shows potent anti-tumor effects in triple-negative breast cancer by activating the PPARΞ³ signaling pathway.
