20 articles
A comprehensive review maps berberine's multi-target mechanisms across cancer, neurological, cardiovascular, and metabolic diseases.
A 10-year review reveals berberine, from the herb Coptidis Rhizoma, fights cancer through apoptosis, autophagy, and gut microbiota modulation.
A comprehensive 2025 review maps berberine's multi-target anti-obesity mechanisms, clinical trial evidence, and strategies to overcome its poor bioavailability.
A 6-year follow-up of a Chinese RCT shows berberine reduced colorectal adenoma recurrence from 52% to 35% even after stopping the drug.
A new study reveals gut microbes convert berberine into dihydroberberine, which blocks a serotonin pathway to protect against cholestatic liver disease.
A natural compound used in traditional Chinese medicine may offer a new treatment for androgenetic alopecia by activating the Wnt/Ξ²-catenin signaling pathway.
Study reveals berberine prevents diabetic kidney disease through Nrf2 pathway activation and ferroptosis inhibition.
New research reveals how berberine protects the heart in diabetes by activating cellular cleanup of harmful fat accumulation.
Combining two traditional herbal compounds fixes a dangerous liver toxicity problem while making colitis treatment significantly more effective.
Reverse network pharmacology pinpoints berberine as a promising treatment for CKM syndrome, validated in a novel mouse model combining metabolic and cardiac stress.
Berberine suppresses ISG15 and pyroptosis to reduce kidney inflammation and fibrosis in diabetic kidney disease, revealing a novel therapeutic mechanism.
A natural alkaloid from traditional Chinese medicine activates a key bile acid receptor to restore intestinal balance and reduce colitis inflammation.
Combining metformin and berberine outperforms either drug alone in reversing NAFLD by powerfully activating the AMPKβSREBP1βFASN lipid-regulation axis.
A traditional Chinese medicine duo β skullcap root and goldthread β reduces fatty liver by simultaneously boosting fat burning and blocking fat synthesis.
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
Bioinspired hydrogel microspheres co-delivering berberine and bone-promoting stem cells eradicate resistant bacteria, quell inflammation, and rebuild bone.
Radix Bupleuri restores liver health by fixing bile acid balance and activating key metabolic pathways in animal studies.
Coptisine targets the STAT1/IRF1/GPX4 axis to halt ferroptosis in Kupffer cells, reducing sepsis-driven liver damage in mice and cell models.
Dendrobium officinale extract protects aging kidneys by activating antioxidant defenses through a key cellular signaling pathway.
Liensinine shifts liver cancer cells from glycolysis to oxidative phosphorylation via AMPK-HIF-1Ξ±, reshaping the tumor immune microenvironment.
