Epigenetic Clocks Predict Alzheimer's Biomarker Changes 15 Years in Advance
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
20 articles
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
DNA methylation biomarkers from a simple blood test may track cognitive aging and neurological disease risk with unprecedented precision.
New AI model using blood tests better predicts brain aging and amyloid buildup linked to dementia risk.
Study of 833 people finds depression linked to premature biological aging in both brain structure and DNA methylation patterns.
New research links age at Parkinson's onset and family history to the likelihood of carrying disease-causing genetic variants.
In CADASIL patients, MRI-derived brain age runs years ahead of chronological age, tracking disease severity and cognitive decline.
New Nature Medicine research links harmful physical and social exposures to accelerated brain aging, with major implications for dementia prevention.
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
Plasma p-tau217 accurately detects preclinical Alzheimer's in cognitively normal adults, potentially enabling earlier intervention.
Revolutionary biofluid markers can identify neurodegenerative diseases early through simple blood tests, transforming prevention.
A streamlined mass spectrometry assay detects preclinical Alzheimer's from just 100 ยตL of blood with AUC 0.81 vs 0.65 for previous methods.
A global consortium reveals how tube type, delays, and storage temperature dramatically skew key Alzheimer's blood biomarker readings.
Researchers develop 98% accurate plasma protein panel that detects ALS disease process years before clinical onset.
New molecular mapping technique identifies individuals uniquely and predicts cognitive decline more accurately than standard brain scans.
A 4-protein panel in neuronal extracellular vesicles outperforms standard plasma tests in flagging early Alzheimer's brain changes.
Researchers developed G-ALPS, an improved brain imaging tool that more accurately tracks cognitive decline and aging.
IRISeq maps gene expression across aging mouse brains, finding lymphocytes fuel neuroinflammation and accelerate cellular aging.
Brain-derived pTau217 blood test shows superior accuracy for detecting Alzheimer's pathology compared to existing tests.
New research identifies specific blood markers that independently predict both physical frailty and cognitive decline.
New research reveals sex differences in Alzheimer's blood biomarkers affect diagnostic accuracy and disease prediction.